Duchenne and Becker Muscular Dystrophies

Brief Description Duchenne and Becker muscular dystrophies are two variants of the same neuromuscular disease characterized by the absence, deficiency or alteration of a protein called dystrophin. These conditions lead to the degeneration of muscle tissue, resulting in a gradual loss of strength and reduction of motor skills. Causes Both forms of muscular dystrophy...
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Spinal Muscular Atrophy (SMA)

Brief Description Spinal Muscular Atrophy (SMA) is a neuromuscular disease that causes the degeneration of motor neurons at the base of the brain and along the anterior horn of the spinal cord, causing muscle weakness. The four main SMA forms differ for onset age, severity, development and transmission mode, but they all affect skeletal muscles of the trunk and limbs ; in...
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Amyotrophic Lateral Sclerosis (ALS)

Brief Description Amyotrophic Lateral Sclerosis (ALS) is a severe neurodegenerative disease that appears in adulthood and affects motor neurons, i.e. the nerve cells that allow the movement of voluntary muscles. It causes the progressive loss of abilities such as swallowing (dysphagia), speech (dysarthria) and control over skeletal muscles, eventually leading to the impai...
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Myasthenia Gravis (MG)

Brief Description Myasthenia Gravis (MG) is an autoimmune disease that causes weakness and rapid fatigue of voluntary muscles. It occurs when the immune system attacks the receptors for acetylcholine, a substance that transmits the impulse from the motor neuron to the muscle, blocking the transmission of nerve impulses to muscles and thus causing an anomalous muscle exhausti...
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Multiple Sclerosis (MS)

Brief Description Also known as disseminated sclerosis, Multiple Sclerosis is a demyelinating neurodegenerative disease that causes lesions to the central nervous system, i.e. the brain, spinal cord and optic nerves. Myelin is the insulating cover that protects axons and allows a rapid and efficient propagation of the signal of the neurons: demyelination is the main cause...
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